2012 Fiscal Year Final Research Report
Excited state of substituted nucleic-acid bases and their oxygen complexes for photodynamic therapy
| Project/Area Number |
22550007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Aoyama Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 核酸塩基 / 励起状態 / 一重項酸素 / 緩和過程 / 光線力学療法 / 近赤外発光 / 過渡吸収 / 光音響法 |
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| Research Abstract |
Excited state and relaxation/reaction processes of S- or N-substituted nucleic-acid bases have been studied by transient absorption spectroscopy, photothermal spectroscopy, near-infrared spectroscopy, and quantum chemical calculations. The quantum yield of the substituted bases was almost unity; however, it strongly depended on the character of the excited singlet state. Non-resonant two-photon absorption spectrum by optical-probing photoacoustic spectroscopy, singlet oxygen formation and its reaction were also discussed. These distinct properties clearly indicate that the substituted bases have a high potential for photodynamic therapy.
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