2012 Fiscal Year Final Research Report
Synthetic Study of Ciguatoxin and Brevisin Based on Intramolecular Allylation
| Project/Area Number |
22550036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Okayama University |
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Principal Investigator |
KADOTA Isao 岡山大学, 大学院・自然科学研究科, 教授 (30250666)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 合成有機化学 / 天然有機化合物 |
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| Research Abstract |
In recent years there has been an explosion of interest in biologically active natural products of marine origin. Due to their structural novelty and toxicity, polycyclic ethers isolated from marine algae are particularly attractive targets for synthetic chemists. Since further biological studies are hampered by the limited availability from nature, chemical synthesis has been the sole realistic way to obtain sufficient amounts of the polycyclic ethers. In this study, convergent synthesis of polycyclic ethers via the intramolecular allyaltion and ring-closing metathesis were examined.
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