2012 Fiscal Year Final Research Report
Model Studies of Nickel Enzymes Included in Carbon Fixation Processes in Nature
| Project/Area Number |
22550059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ニッケル酵素 / アセチル CoA合成酵素 / メチル CoM還元酵素 / チオラート / 炭素固定 / メタン生成 |
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| Research Abstract |
Nickel complexes modeling acetyl CoA synthase (ACS) and methylCoM reductase (MCR) were synthesized in order to investigate their structures and reactions wereto obtain clues to the unrevealed reaction mechanisms. Synthesis of a series of dinuclear nickelcomplexes having tetra-anionic diamido-dithiolate ligand mbpa modeling the plausibleintermediates of the catalytic reaction was achieved. As for MCR model complexes, the nickel(II)cyclams coordinated by methyl CoM sulfonate as an inactive form model and the nickel(I) cyclamsmodeling the active reduced state were synthesized.
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[Remarks] Angew. Chem. Int. Ed. 2010, 49,4209-4212の中表紙 成果は論文誌の表紙等に取り上げられた
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[Remarks] Chem. Asian J. 2012, 7, 920-929の中表紙 成果は論文誌の表紙等に取り上げられた
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[Remarks] Inorg. Chem. 2012, 51, 5173-5187の表紙 成果は論文誌の表紙等に取り上げられた
