2012 Fiscal Year Final Research Report
Synthesis of macrolactin A and itsderivatives using Z-selective intramolecular Horner-Wadsworth-Emmons reaction
| Project/Area Number |
22550095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Synthetic chemistry
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| Research Institution | Gifu University |
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Principal Investigator |
ANDO Kaori 岐阜大学, 工学部, 教授 (70211018)
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| Co-Investigator(Renkei-kenkyūsha) |
OKA Natsuhisa 岐阜大学, 工学部, 准教授 (50401229)
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| Project Period (FY) |
2010 – 2012
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| Keywords | マクロラクチンA / 分子内HWE反応 / Z-選択的 / 誘導体合成 |
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| Research Abstract |
Intramolecular Horner-Wadsworth-Emmons reaction of the substrates (ArO)2P(O)CH2CO2…CHO gave the 12- to 18-membered-ring Z-lactones highly selectively. While, the substrates (RO)2P(O)CH2CO2…CHO gave the E-lactones highly selectively. The synthesis of a macrolactin A derivative was performed by this method.
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