2012 Fiscal Year Final Research Report
Development of Novel Catalysts Utilizing Monoclonal Antibodies Specific for Optically Active Compounds with Thermoresponsive Particles
| Project/Area Number |
22550112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Akira 大阪大学, 大学院・理学研究科, 教授 (80127282)
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| Project Period (FY) |
2010 – 2012
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| Keywords | モノクローナル抗体 / 立体特異性 / キラル / 分子認識 / 熱応答性 / ビナフチル誘導体 |
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| Research Abstract |
Monoclonal antibodies are considered to be one of the suitable proteins which can be used as a tailor-made chiral recognition reagent. In this study, a chiral binaphthyl derivative waschosen as a target molecule (hapten) which is a precursor for 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP), a widely used ligand in asymmetric metal-catalyzed reactions. Wedemonstrated that one of the monoclonal antibodies elicited against the binaphthyl derivative coulddifferentiate one of the enantiomers. We could clearly visualize chiral recognition events of the antibody by using poly-N-isopropylacrylamide (pNIPAM) bearing the chiral binaphthyl derivative.
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[Presentation]2012
Author(s)
Yamaguchi, H.; Hashidzume, A.; Takashima, Y.; Harada, A
Organizer
The 9th SPSJ International Polymer Conference
Place of Presentation
神戸国際会議場 (神戸市).
Year and Date
2012-12-13
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