2012 Fiscal Year Final Research Report
Preparation of film materials made of biological polysaccharidesand their composite formation with apatite
| Project/Area Number |
22550155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生体材料 / フィルム / 多糖 / 熱プレス / 細胞 / ドラッグデリバリーシステム / ファイバー |
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| Research Abstract |
The preparation process to obtain water-insoluble films of biological polysaccharides was established by hot pressing of polyion complexes made of glycosaminoglycans and chitosan. The optimal condition for each polysaccharide combination was clarified. Effects of structure and molecular weight of polysaccharides on physical properties of the resulting films were evaluated. Hydroxyapatite deposition on these films under body fluid conditions was achieved. To obtain larger sizes of the films rapidly, improvement of the film preparation process was also examined.
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