2012 Fiscal Year Final Research Report
y -Cyclodextrin-polyurethane copolymer adsorbent for selective removalof endotoxin from DNA solution
| Project/Area Number |
22550200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Kumamoto University |
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Principal Investigator |
SAKATA Masayo 熊本大学, 大学院・自然科学研究科, 准教授 (60187391)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Mitsuru 熊本大学, 大学院・自然科学研究科, 准教授 (40363519)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 高分子微粒子 / エンドトキシン / LPS 吸着剤 / DNA 分離 / 包接作用 / 選択吸着 |
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| Research Abstract |
The copolymer particles for removal of lipopolysaccharide (LPS)were prepared by suspension copolymerization of -cyclodextrin (CyD) and1,6-hexamethylenediisocyanate. The copolymer (CyD content: 14-20 mol%) could selectivelyremoved LPS from a DNA solution (50 g/ml) containing LPS (15 EU/ml) at pH 6 and ionicstrength (u) of 0.05-0.2.
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Research Products
(27 results)
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[Journal Article] Photochemicalengineering of graphene oxide nanosheets2012
Author(s)
M. Koinuma, C. Ogata, Y. Kamei, K.Hatakeyama, H. Tateishi, Y. Watanabe, T.Taniguchi, K. Gezuhara, S. Hayami, A.Funatsu, M. Sakata, Y. Kawahara, S.Kurihara, Y. Matsumoto
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Journal Title
Journal of Physical Chemistry C
Volume: Vol.116, No.37
Pages: 19822-19827
Peer Reviewed
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[Remarks] DNA ワクチンの製造時、有害物質除く吸着剤、日本経済新聞, 2012.10.25, 35 面
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[Remarks] ワクチンから有毒物質除去、熊本日日新聞,2012.10.31, 32 面
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