2012 Fiscal Year Final Research Report
Integration of pleiotropic signals involved in the telomere integrity
| Project/Area Number |
22570002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Chiba University |
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Principal Investigator |
AKIRA Matsuura 千葉大学, 大学院・融合科学研究科, 教授 (10272692)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ゲノム恒常性 / テロメア / 細胞周期 / チェックポイント / シグナル伝達 / 細胞老 化 |
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| Research Abstract |
CST (Cdc13-Stn1-Ten1) complex of the budding yeast Saccharomyces cerevisiae has been shown to associate with the telomeric DNA ends and to be involved in telomere replication and protection. Stn1 was phosphorylated by Cdk during specific times during the cell cycle, and the phosphorylation regulated telomere elongation negatively. In addition, we found that an stn1 mutant defective in its protective function resulted in telomere elongation via the recombination- and telomerase-dependent mechanisms. Moreover, we found that telomere shortening-mediated cellular senescence induced autophagy by regulating the TOR-signaling pathway and the telomere-binding protein Rap1.
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[Journal Article] A steroidal saponin from Ophiopogon japonicus extends the lifespan of yeast via SOD and UTH1.2013
Author(s)
Sun, K., Cao, S., Pei, L., Matsuura, A., Xiang, L., and Qi, J.
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Journal Title
Int. J. Mol. Sci.
Volume: 14
Pages: 4461-4475
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[Journal Article] Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression2012
Author(s)
Sun, K., Xiang, L., Ishihara, S., Matsuura, A., Sakagami, Y., and Qi, J.
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Journal Title
Biosci. Biotechnol. Biochem
Volume: 76
Pages: 640-645
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[Journal Article] Ganodermasides C and D, two new anti-aging ergosterols from the spores of a medicinal mushroom Ganoderma lucidum. Biosci2011
Author(s)
Weng, Y., Lu, J., Xiang, L., Matsuura, A., Zhang, Y., Huang, Q., and Qi, J.
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Journal Title
Biotechnol. Biochem
Volume: 75
Pages: 800-803
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[Journal Article] Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor2011
Author(s)
Xiang, L., Nakamura, Y., Lim, Y.M., Yamasaki,Y., Kurokawa-Nose, Y., Maruyama, W., Osawa, T., Matsuura, A., Motoyama, N., and Tsuda, L.
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Journal Title
Aging
Volume: 3
Pages: 1098-1109
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[Journal Article] Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene2010
Author(s)
Weng, Y., Xiang, L., Matsuura, A., Zhang, Y., Huang, Q., and Qi, J.
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Journal Title
Bioorganic & Medicinal Chemistry
Volume: 18
Pages: 999-1002
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