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2012 Fiscal Year Final Research Report

Onset of endoreplication through the regulation of G2/M phase during the cell cycle

Research Project

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Project/Area Number 22570040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plant molecular biology/Plant physiology
Research InstitutionNagoya University

Principal Investigator

ITO Masaki  名古屋大学, 生命農学研究科, 准教授 (10242851)

Project Period (FY) 2010 – 2012
Keywords細胞分裂 / 細胞周期 / エンドリプリケーション / 核内倍加 / 植物 / ユビキチンリガーゼ / 転写制御
Research Abstract

Plant cells often increase their cellular DNA content (ploidy) during plant development, through the modified cell cycle where DNA replication occurs repeatedly without intervening cell division. Although it has been generally believed that increased cellular ploidy may be important for the control of cell size, metabolic activity, and cell differentiation, little is known about the regulatory mechanisms of this processes. In this study, we have focused on the two factors, GIG1 and SCL, that may have important roles in increasing cellular ploidy. We showed that GIG1 may negatively regulate ploidy increase by inhibiting a specific protein degradation system acing during G2 and mitosis. On the other hand, SCL may accelerate increasing ploidy by transcriptional repression of genes involved in DNA replication, possibly during M phase in the cell cycle.

  • Research Products

    (17 results)

All 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (11 results)

  • [Journal Article] Cell cycle modules in plants for entry into proliferation and for mitosis. In J. Greilhuber et al., eds.2013

    • Author(s)
      Magyar, Z., Ito, M., Binarova, Mohamed, B., Bogre, L.
    • Journal Title

      Plant Genome Diversity

      Volume: Vol. 2 Pages: 77-97

    • DOI

      DOI:10.1007/978-3-7091-1160-4_6

  • [Journal Article] Virus-induced silencing of NtmybA1 and NtmybA2 causes incomplete cytokinesis and reduced shoot elongation in Nicotiana benthamiana2012

    • Author(s)
      Araki, S., Machida, Y., Ito, M.
    • Journal Title

      Plant Biotechnology

      Volume: 29 Pages: 483-487

    • DOI

      DOI:10.5511/plantbiotechnology.12.1004a

    • Peer Reviewed
  • [Journal Article] Roles of GIG1 and UVI4 in genome duplication in Arabidopsis thaliana.2012

    • Author(s)
      Iwata, E., Ikeda, S., Abe, N., Kobayashi, A., Kurata, M., Matsunaga, S., Yoshioka, Y., Criqui, M.-C., Genschik, P., Ito, M.
    • Journal Title

      Plant Signal. Behav.

      Volume: 7 Pages: 1079 -1081

    • DOI

      DOI:10.4161/psb.21133

    • Peer Reviewed
  • [Journal Article] GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.2011

    • Author(s)
      Iwata, E., Ikeda, S., Matsunaga, S., Kurata, M., Yoshioka, Y., Criqui, M-C, Genschik, P., Ito, M
    • Journal Title

      Plant Cell

      Volume: 23 Pages: 4382-4393

    • DOI

      DOI:10.1105/tpc.111.092049

    • Peer Reviewed
  • [Journal Article] Agrobacterium rhizogenes-mediated transformation of the parasitic plant Phtheirospermum japonicum.2011

    • Author(s)
      Ishida, J.K., Yoshida, S., Ito, M., Namba, S., Shirasu K.
    • Journal Title

      PLoS One

      Volume: 6 Pages: e25802

    • DOI

      DOI:10.1371/journal.pone.0025802

    • Peer Reviewed
  • [Journal Article] Mutations in MYB3R1 and MYB3R4 cause pleiotropic developmental defects and preferential down-regulation of multiple G2/M-specific genes in Arabidopsis thaliana.2011

    • Author(s)
      Haga, N., Kobayashi, K., Suzuki, T., Maeo, K., Kubo, M., Ohtani, M., Mitsuda, N., Demura, T., Nakamura, K., Jurgens, G., Ito, M.
    • Journal Title

      Plant Physiol

      Volume: 157 Pages: 706-717

    • DOI

      DOI:10.1104/pp.111.180836

    • Peer Reviewed
  • [Presentation] R1R2R3-Myb transcriptional repressors are important for developmentally controlled expression of G2/M-specific genes2013

    • Author(s)
      Eriko Iwata, Norihito Nakamichi, Masaki Ito
    • Organizer
      第54回日本植物生理学会年会
    • Place of Presentation
      岡山大学
    • Year and Date
      2013-03-21
  • [Presentation] Negative regulators of APC/C as determinants of ploidy levels2012

    • Author(s)
      Masaki Ito
    • Organizer
      10th International Congress of Plant Molecular Biology
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2012-10-25
  • [Presentation] ゲノム倍加を制御する新奇APC/C阻害タンパク質2012

    • Author(s)
      伊藤正樹
    • Organizer
      日本植物学会第76回大会
    • Place of Presentation
      兵庫県立大学
    • Year and Date
      2012-09-17
  • [Presentation] Cellular ploidy levels are regulated by novel inhibitor proteins of APC/C during organ development in Arabidopsis2012

    • Author(s)
      Masaki Ito, Eriko Iwata, Saki Ikeda, Asuka Kobayashi, Natsumi Abe, Mariko Kurata
    • Organizer
      23th International Conference on Arabidopsis Research
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2012-07-05
  • [Presentation] 新奇APC/C 阻害タンパク質をコードするGIG1 とUVI4の機能分担2012

    • Author(s)
      池田早希、岩田恵里子、倉田真理子、松永幸大、 伊藤正樹
    • Organizer
      第53回日本植物生理学会年会
    • Place of Presentation
      京都産業大学
    • Year and Date
      2012-03-17
  • [Presentation] APC/C 阻害因子を欠失したgigas cell1 変異体における細胞運命決定の異常2012

    • Author(s)
      岩田恵里子、池田早希、倉田真理子、松永幸大、 伊藤正樹
    • Organizer
      第53回日本植物生理学会年会
    • Place of Presentation
      京都産業大学
    • Year and Date
      2012-03-16
  • [Presentation] GIGAS CELL1, a novel negative regulator of APC/C, is required for proper mitotic progression and cell fate determination in Arabidopsis thaliana2011

    • Author(s)
      Masaki Ito
    • Organizer
      International Symposium "Strategies of Plants against Global Environmental Change"
    • Place of Presentation
      倉敷市芸文館
    • Year and Date
      2011-12-10
  • [Presentation] 体細胞の染色体数が倍加するシロイヌナズナgigas cell1変異体の解析2011

    • Author(s)
      岩田恵里子、松永幸大、吉岡泰、伊藤正樹
    • Organizer
      日本植物学会第75回大会
    • Place of Presentation
      東京大学駒場キャンパス
    • Year and Date
      2011-09-17
  • [Presentation] 巨大な孔辺細胞様の細胞が生じるシロイヌナズナgig1変異体の解析2010

    • Author(s)
      岩田恵里子、吉岡泰、松永幸大、伊藤正樹
    • Organizer
      日本植物学会弟74回大会
    • Place of Presentation
      中部大学
    • Year and Date
      2010-09-11
  • [Presentation] APC/C 阻害因子を欠失した gigas cell1 変異体における細胞運命決定の異常2010

    • Author(s)
      岩田恵里子、松永幸大、吉岡泰、伊藤正樹
    • Organizer
      日本植物学会弟74回大会
    • Place of Presentation
      中部大学
    • Year and Date
      2010-09-09
  • [Presentation] Myb proteins acting as transcriptional repressors for G2/M phase-specific genes2010

    • Author(s)
      Kosuke Kobayashi, John Doonan, Taku Demura, Marie-Theres Hauser, Masaki Ito
    • Organizer
      21st International Conference on Arabidopsis Research
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-06-07

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Published: 2014-08-29  

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