2012 Fiscal Year Final Research Report
Screening of novel checkpoint-related proteins in higher plants
| Project/Area Number |
22570055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
SAKAMOTO Ayako 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究主幹 (00354960)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 環境応答 / チェックポイント / 細胞周期 / DNA 損傷 |
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| Research Abstract |
To investigate the molecular mechanism of cell-cycle checkpoint in higher plants, we analyzed the proteins that are specifically phosphorylated after DNA damage or replication inhibition, and found several candidates for checkpoint proteins. We also analyzed the function of TLS-type DNA polymerases that are thought to work downstream of the checkpoint response, and found that some polymerases induce mutations and regulate somatic recombination activities
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