2012 Fiscal Year Final Research Report
Glucose transport pathways in the cochlear stria vascularis
| Project/Area Number |
22570064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Okayama University |
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Principal Investigator |
ANDO Motonori 岡山大学, 大学院・教育学研究科, 教授 (20222789)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 辺縁細胞 / 基底細胞 / グルコーストランスポーター / GLUT / SGLT / HMIT |
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| Research Abstract |
The present study provides the first evidence that mRNAs of eight GLUT isoforms are expressed in the stria vascularis and the spiral ligament. These GLUT isoforms are suspected to involve in the high metabolic activity of the stria vascularis, and to play specific roles in maintenance of cochlear glucose homeostasis. Among these isoforms, GLUT1, -4 and -10 proteins were expressed in the strial basal cells. These findingsvalidate the transcellular glucose pathway from perilymph to intrastrial space via the basal cell layer. We also demonstrated that GLUT13 (HMIT) was expressed in the strial marginal cells, and speculate that HMIT in the marginal cells may be involved in PI synthesis, osmoregulation, and pH homeostasis of cochlear fluids.
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