2012 Fiscal Year Final Research Report
Physiological roles of insulin-like growth factor binding protein 3 in mouse endometrium
| Project/Area Number |
22570066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Okayama University |
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Principal Investigator |
TAKAHASHI Sumio 岡山大学, 大学院・自然科学研究科, 教授 (90144807)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞増殖 / 成長因子 / 子宮 / インスリン様成長因子1 / インスリン様成長因子結合タンパク質3 / 発情ホルモン / マウス |
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| Research Abstract |
IGFBP3 inhibited IGF1-induced proliferation of endometrial cells. Igfbp3 mRNA expression in the endometrial stromal cells was decreased by estradiol-17β(E2) and TGFα.MMP3 and Kallikrein (Klk) 1 degrade IGFBP3. Mmp3mRNA expression was increased by TGFα, and Klk1mRNA expression was by E2. Enhanced production of MMP3 and Klk1 decrease IGFBP3 levels in the endometrium, resulting in the increase in free IGF1 levels. E2 increased Igf1mRNA expression.These findings provide the possible regulatory mechanism of endometrialstromal cell proliferation that E2 stimulates IGF1 production, while E2 and TGFαdecrease IGFBP3 level, leading to the stimulation of endometrial cell proliferation.
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[Journal Article] Runx3 expression and its roles in mouse endometrial cells2012
Author(s)
Tsuchiya, Y., Saito, Y., Taniuchi, S., Sakuma, A., Maekawa, T., Fukamachi, H., Takeuchi, S., Takahashi, S
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Journal Title
Journal of Reproduction and Development
Volume: 58巻
Pages: 592-598
DOI
Peer Reviewed
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[Journal Article] Transforming growthfactor-・ mRNA expression and its possible roles in mouse endometrial stromal cells2012
Author(s)
Maekawa, T., Sakuma, A., Taniuchi, S., Ogo, Y., Iguchi, T., Takeuchi, S., Takahashi, S
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Journal Title
Zoological Science
Volume: 29巻
Pages: 377-383
DOI
Peer Reviewed
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