2012 Fiscal Year Final Research Report
Structure and functional analysis of the GCase receptor by x-ray
| Project/Area Number |
22570110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OGAWA Haruo 東京大学, 分子細胞生物学研究所, 准教授 (40292726)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 受容体 / ANP / ホルモン / 膜受容体 / 膜蛋白質 |
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| Research Abstract |
ANP receptor, which belongs to a member of guanylyl cyclase (GCase) receptor family,plays a key role in the regulation of blood pressure and body fluid balance in our body.The mechanisms "how the GCase receptor recognizes hormone" and "how the receptortransmits the hormone-binding signal to its intracellular domain” are still unknown.To elucidate the mechanisms, we performed x-ray crystallography of the ANP receptorextracellular domain complexed with ligands and kinetics experiments of the receptor.
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