2012 Fiscal Year Final Research Report
Functional analysis of fatty acid-binding proteins (FABPs) involved in nuclear receptor signaling
| Project/Area Number |
22570112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 核内受容体 / 脂肪酸結合タンパク質 / 脂肪酸 / 胆汁酸 / シグナル伝達 / 遺伝子発現 / 癌転移 / miRNA |
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| Research Abstract |
(1) Functional analysis of FABP5 in nuclear receptor PPAR signaling in carcinogenesis or metastasis: I have found that nuclear receptor PPAR target gene, FABP5, is up-regulated in human malignant prostate cancer cellsand that is localized into the nucleus in a ligand (fatty acid)-dependent manner.
(2)Functional analysis of FABP6 in nuclear receptor FXR signaling: I have identified novel miRNAs and their target genes that were activated by the FXR agonist. Furthermore, I have demonstrated that a variant protein for FABP6, called FABP6-L/IBABP-L, has exhibited anti-apoptotic activity in the presence of bile acid in colorectal cancer cells.
(3) Activation mechanisms of FABP5 gene expression: I have found that DNA methylation status of FABP5 gene isolated from PC-3 is much more demethylated compared withthat of the gene from PNT-2.
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[Journal Article] Hatakeyama Diagnosis of ischemic small bowel disease by measurement of serum intestinal fatty acid-binding protein in patients with acute abdomen: a multicenter, observer-blinded validation study.2011
Author(s)
T. Kanda, A. Tsukahara, K. Ueki, Y. Sakai, T. Tani, A. Nishimura, T. Yamazaki, Y. Tamiya, T. Tada, M. Hirota, J. Hasegawa, H. Funaoka, H. Fujii, K.
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Journal Title
J. Gastroenterology
Volume: 46
Pages: 492-500
Peer Reviewed
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