2012 Fiscal Year Final Research Report
Structural and functional analysis of GDE family proteins
| Project/Area Number |
22570117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
AOYAMA Hiroshi 大阪大学, 大学院・薬学研究科, 准教授 (60291910)
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| Co-Investigator(Renkei-kenkyūsha) |
OHSHIMA Noriyasu 群馬大学, 大学院・医学研究科, 助教 (30360514)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 膜タンパク質 / X 線結晶構造解析 / 構造生物学 / 脂質代謝 |
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| Research Abstract |
For elucidation of the reaction mechanism of glecerophoshodiesterphosphodiesterase family protein (GDE1～7), studies on the structures and functions of GDE were carried out. Crystals of mouse membrane protein GDE1 were obtained in several new crystallization conditions including magnesium ion. These crystals diffracted up to 3.0Å resolution, and we are analyzing these data to determine the structure.
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[Journal Article] A novel glycerophosophodiester phosphodiesterase GDE5 controls skeletal muscle development via a non-enzymatic mechanism2010
Author(s)
Okazaki Yuri, Ohshima Noriyasu, Yoshizawa Ikumi, Kamei Yasutomi, Masiggio Stefania, Okamoto Keiko, Maeda Masahiro, Nogusa Yoshihito, Fujioka Yuichiro, Izumi Takashi, Ogawa Yoshihiro, Shiro Yoshitsugu, Wada Masanobu, Kato Norihisa, Corda
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 27652-27663
Peer Reviewed
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