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2012 Fiscal Year Final Research Report

Interaction between Innate Immune Receptor CD14 and Ligand LPS on Membranes

Research Project

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Project/Area Number 22570127
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Structural biochemistry
Research InstitutionSuntory Foundation for Life Sciences

Principal Investigator

三浦 薫 (野村 薫)  公益財団法人サントリー生命科学財団, 生物有機科学研究所, 研究員 (90353515)

Co-Investigator(Renkei-kenkyūsha) SHIMAMOTO Keiko  公益財団法人サントリー生命科学財団, 生物有機科学研究所, 主幹研究員 (70235638)
KUSUMOTO Shoichi  公益財団法人サントリー生命科学財団, 生物有機科学研究所, 所長 (30028253)
Project Period (FY) 2010 – 2012
KeywordsGPIアンカー / 固体NMR法 / 脂質二重膜 / 自然免疫 / 酵母培養系
Research Abstract

To complete the methodology, we changed the procedure into using a model membrane. We succeeded in obtaining high resolution solid-state NMR spectra of membrane samples in which pseudo GPI-anchored proteins were inserted

  • Research Products

    (10 results)

All 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] "Hydration and Temperature Dependence of 13C and 1H NMR Spectra of the DMPC Phospholipid Membrane and Complete Resonance Assignment of Its Crystalline State."2011

    • Author(s)
      K. Nomura, M. Lintuluoto, and K. Morigaki
    • Journal Title

      J. Phys.Chem

      Volume: vol. 115 Pages: 14991-15001

    • Peer Reviewed
  • [Journal Article] "Lipopolysaccharide induces raft domain expansion in membrane composed of a phospholipid-cholesterol-sphingomyelin ternary system."2011

    • Author(s)
      K. Nomura, M. Maeda, K. Sugase and S.Kusumoto
    • Journal Title

      Innate Immun

      Volume: vol. 17 Pages: 256-268

    • Peer Reviewed
  • [Journal Article] "Fluorinated cholesterol retains domain-forming activity in sphingomyelin bilayers."2011

    • Author(s)
      N. Matsumori, H. Okazaki, K. Nomura and M. Murata
    • Journal Title

      Chem. Phys. Lipids

      Volume: vol. 164 Pages: 401-408

    • Peer Reviewed
  • [Presentation] "Hydration and Temperature Dependence of 13C and 1H NMR Spectra of the DMPC Phospholipid Membrane and Complete Resonance Assignment of Its Crystalline State."2011

    • Author(s)
      K. Nomura
    • Organizer
      The International Symposium on Nuclear Magnetic Resonance 2011(招待講演)
    • Place of Presentation
      大桟橋ホール、横浜市
    • Year and Date
      20111115-18
  • [Presentation] "Hydration and Temperature Dependence of 13C and 1H NMR Spectra of the DMPC Phospholipid Membrane and Complete Resonance Assignment of Its Crystalline State."2011

    • Author(s)
      K. Nomura
    • Organizer
      International ERATO Symposium on Lipid Structures in and around Proteins (招待講演)
    • Place of Presentation
      ホテル阪急エキスポパーク、吹田市
    • Year and Date
      20111111-14
  • [Presentation] "Lipopolysaccharide induces raft domain expansion in a phospholipid-cholesterol-sphingomyelin ternary system."2010

    • Author(s)
      K. Nomura
    • Organizer
      PACIFICHEM 2010 Advances in Solid-State NMR of Biomlogical Molecules.(招待講演)
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      20101213-18
  • [Presentation] "Lipopolysaccharide induces raft domain expansion in a phospholipid-cholesterol-sphingomyelin ternary system."2010

    • Author(s)
      K. Nomura
    • Organizer
      system."SLB (Society of Leukocyte Biology) / IEIIS (International Endotoxin and Innate Immunity Society) 2010 Annual meeting
    • Place of Presentation
      Vancouver、 Canada
    • Year and Date
      20101007-09
  • [Presentation] "自然免疫の鍵物質リポ多糖と脂質膜の相互作用解析2010

    • Author(s)
      野村 薫
    • Organizer
      "固体NMR材料フォーラム「―固体NMR研究の最前線―」(招待講演)
    • Place of Presentation
      神戸製鉄所、神戸市
    • Year and Date
      20100510-11
  • [Book] "Lipopolysaccharide Induces Raft Domain Expansion in a Cholesterol-ContainingMembrane"in "Advances in Biological Solid-State NMR: Proteins and Membrane-Active Peptides"

    • Author(s)
      K. Nomura and S. Kusumoto
    • Publisher
      RSC Publishing,
  • [Remarks]

    • URL

      http://www.sunbor.or.jp

URL: 

Published: 2014-08-29   Modified: 2015-05-22  

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