2012 Fiscal Year Final Research Report
A novel function of RNA in the regulation of chromatin structure
| Project/Area Number |
22570132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | クロマチン / 核小体 / リボソーム / RNP複合体 / RNA / ヒストンシャペロン |
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| Research Abstract |
The aim of this study was to identify RNA molecules involved in chromatin regulation by focusing on RNA-binding histone chaperone Nucleophosmin/B23. We found that B23 was recruited to the rRNA gene loci by using its RNA binding activity. In addition, we clarified the molecular mechanism by which B23 binds to specific RNA target. Furthermore, we identified RNA molecules specifically bound by B23 in vivo. This study will contribute to understand the regulation mechanism of chromatin structure.
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