2012 Fiscal Year Final Research Report
Studies on the mechanisms of functional differentiation of taste bud cells
| Project/Area Number |
22570134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
EMORI Yasufumi 東京大学, 大学院・理学系研究科, 准教授 (60160389)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 味覚 / 味蕾 / 分化 / 転写因子 |
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| Research Abstract |
Taste bud cells, belonging to epithelialcelllineage, play essential roles in taste perception, and continuously turnover even in the adult stage. Many aspects about their differentiation are unknown, then, in this study, I searched for transcription factors expressed in taste bud cells, and investigated the expression and function of these factors. As a result, I found two factors of MEF2 and NFAT families, and found that they begin to express concomitantly with the differentiation of type II cells which have main taste sensations. In addition, the regulatory process is related to the calcium signaling of taste transduction.
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