2012 Fiscal Year Final Research Report
The mechanisms of histone balance control coupling with chromatin assembly
| Project/Area Number |
22570174
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Nagoya City University |
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Principal Investigator |
TAGAMI Hideaki 名古屋市立大学, 大学院・システム自然科学研究科, 准教授 (70273216)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ヒストン / クロマチン構造 / ヒストン複合体 / Mlo2 / Cia1 |
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| Research Abstract |
Chromatin assembly is controlled strictly in association with genome integrity. In this study, in order to elucidate the molecular basis of histone balance control system, we purified the soluble histone complexes as reaction intermediates. We identified a novel soluble H3 binding factor in fission yeast. Further biochemical and genetic analyses suggest a new aspect for soluble H3 level control and cell growth.
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