2012 Fiscal Year Final Research Report
Studies on the inner nuclear structure of the cell based on proteome and phosphoproteome analyses
| Project/Area Number |
22570181
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Kazuhiro 新潟大学, 自然科学系, 教授 (40229109)
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| Project Period (FY) |
2010 – 2012
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| Keywords | プロテオーム / ホスホプロテオーム / 細胞核 / 核小体 / WDタンパク質 / リボソーム形成 |
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| Research Abstract |
We previously proposed the dynamic scaffold model for inner nuclear structure formation. In this model, structures in inter-chromatin regions comprise dynamically formed protein complexes, and WD repeat-proteins and others act as scaffolds for these protein complexes. In this study, fourteen WD-repeat proteins found in a nuclear matrix fraction were studied on the localization and dynamics in the living cells and association and dissociation with other proteins to evaluate the model. These results and others supported the dynamic scaffold model.
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