2012 Fiscal Year Final Research Report
Signal transduction in myxobacteria using eukaryotic protein kinas es and phosphatases.
| Project/Area Number |
22570187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEGAWA Kaoru 九州大学, 農学研究院, 教授 (50197282)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 粘液細菌 / Ser/Thr/Tyr プロテインホスファターゼ / 細菌型チロシンキナーゼ |
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| Research Abstract |
Myxococcus xanthus btkB gene is expressed mainly in the growth phase and early stages of fruiting body development. When cultured in nutrient medium at high temperature (37 °C), btkB mutant showed reduced maximum cell density as compared to the wild type. Also, phosphorylated BtkA is expressed late after starvation induction and early after glycerol induction, and BtkA is required for the formation of mature spores.BtkA and BtkB are involved in the synthesis of exopolysaccharide. On the other hand, Php3 showed the enzymatic characteristics of PP2C-type serine/threonine protein phosphatases, and is involved in spore formation. PhpA shares homology with PHP family, and dephosphorylates Tyr-phosphorylated BtkA and BtkB. This enzyme is also involved in the production of exopolysaccharide.
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[Journal Article] A Myxococcus xanthus bacterial tyrosine kinase, BtkA, is required for the formation of mature spores.2011
Author(s)
Kimura, Y., Yamashita, S., Mori, Y., Kitajima, Y., and Takegawa, K.
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Journal Title
Journal of Bacteriology
Volume: 193
Pages: 5853-5857
DOI
Peer Reviewed
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