2012 Fiscal Year Final Research Report
Identification of localization factor for cadherin-catenin complex in epithelial cells
| Project/Area Number |
22570188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YONEMURA Shigenobu 独立行政法人理化学研究所, 電子顕微鏡解析室, 室長 (60192811)
SHIMAMURA Kenji 熊本大学, 発生医学研究所, 教授 (70301140)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞間相互作用 / 細胞外マトリックス / 上皮極性 |
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| Research Abstract |
In this study, we succeeded in the isolation of cadherin‐catenin‐deficient mouse F9 cells as a tool to identify the epithelial factor, which determine the localization of cadherin‐catenin complex in epithelial cells. Using the cadherin‐catenin‐deficient F9 cells, we perceive the possibility that there is a novel adhesion mode in undifferentiated F9 cells, which is independent of actin‐based cytoskeletons. We also suggested the presence of an unexpected factor, which regulate localization of cadherin-catenin complex in non‐epithelial cells.
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