2012 Fiscal Year Final Research Report
Analysis of mechanism for neural-epidermal boundary formation
| Project/Area Number |
22570200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MICHIUE Tatsuo 東京大学, 大学院・総合文化研究科, 准教授 (10282724)
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Hiroki 静岡大学, 大学院・教育学研究科, 准教授 (70402229)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 形態形成 |
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| Research Abstract |
In this study, (1)We analyzed the function of PRDM12. When PRDM12 MO was injected, the expression of several placode formation was specifically inhibited. (2) We found that suitable dose of BMP/Wnt inhibitor efficiently induced placode. (3) The analysis of Xnr3 indicated that injection with Xnr3 effected on the shape of cells locatedin neural-epidermal border region, and that the expression of placode marker and brain marker was altered.
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[Journal Article] Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder- and Serum-Free Defined Conditions2010
Author(s)
Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, OhnumaK, Nakauchi H, Asashima M
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Journal Title
PLoS One
Volume: 5
Pages: e14099
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[Journal Article] Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture2010
Author(s)
Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Furue MK
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Journal Title
Int J Dev Biol
Volume: 54
Pages: 1287-94
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[Presentation]2012
Author(s)
Nejigane S, Michiue T, Asashima M.
Organizer
14th international Xenopus conference
Place of Presentation
Hyeres, France
Year and Date
20120000
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[Presentation] Establishment of an efficient neural crest cell induction system from mouse embryonic stem cells in defined medium2011
Author(s)
Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Kusuda-Furue M.
Organizer
9th International Society for StemCell Research annual meeting
Year and Date
20110000
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