2012 Fiscal Year Final Research Report
Studies on the overexpression of insect cytochrome P450s for the molecular identification of insecticide resistance
| Project/Area Number |
22580064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied entomology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TOMITA Takashi 国立感染症研究所, 昆虫医科学部, 室長 (20180169)
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| Co-Investigator(Kenkyū-buntansha) |
KASAI Shinji 国立感染症研究所, 昆虫医科学部, 主任研究官 (80332360)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMAGATA Osamu 国立感染症研究所, 昆虫医科学部, 研究員 (20435712)
ITOKAWA Kentaro 国立感染症研究所, 昆虫医科学部, 流動研究員
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| Project Period (FY) |
2010 – 2012
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| Keywords | 害虫管理 / 生物的防除 |
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| Research Abstract |
Cytochrome P450 genes genetically overexpressing and associated with each of larval and adult pyrethroid resistance in Culex quinquefasciatus were studied. We demonstrated that the overexpression of CYP9M10 due to cis-acting mutations is globally addressed to at least larval metabolic resistance to pyrethroids in this species and established a molecular genotyping method for identifying overexpressing CYP9M10 haplotypes.
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[Journal Article] Global spread and genetic variants of the two CYP9M10 haplotype forms associated with insecticide resistance in Culex quinquefasciatus Say.2013
Author(s)
Itokawa, K., Komagata, O., Kasai, S., Kawada, H., Mwatele, C., Dida, G., Njenga, S., Mwandawiro, C., Tomita, T
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Peer Reviewed
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