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2012 Fiscal Year Final Research Report

Regulation mechanism of intracellular coenzyme A by pantothenate kinase in microbes

Research Project

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Project/Area Number 22580075
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied microbiology
Research InstitutionIbaraki University

Principal Investigator

CHOHNAN Shigeru  茨城大学, 農学部, 准教授 (70312775)

Project Period (FY) 2010 – 2012
Keywordsパントテン酸キナーゼ / コエンザイムA / 真正細菌 / 古細菌
Research Abstract

Coenzyme A (CoA) functions as a carbon carrier. To clarify the regulation mechanism of the biosynthetic pathway of this important coenzyme, pantothenate kinase (CoaA) being the key enzyme was analyzed, and the following points were clarified. i) The enzymes which function in archaeal CoA biosynthetic pathway are not CoaAs which is commonly used in bacteria and eukaryotes but the intrinsic ones to archaea. ii) Two CoaA homologues in Bacillus subtilis have the enzyme activity, suggesting the possibility that both CoaAs are active in vivo.

  • Research Products

    (8 results)

All 2013 2012 2011 2010 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Identification of pantoate kinase and phosphopantoate synthetase from Methanospirillum hungatei2013

    • Author(s)
      Hiroki Katoh, Hideyuki Tanaki, Yuka Tokutake, Satoshi Hanada, Shigeru Chohnan
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 115巻 Pages: 372-376

    • DOI

      doi:10.1016/j.jbiosc.2012.10.019

    • Peer Reviewed
  • [Presentation] 枯草菌のコエンザイムA生合成2013

    • Author(s)
      緒形雄太、朝山宗彦、長南茂
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学
    • Year and Date
      2013-03-26
  • [Presentation] Characterization of prokaryotic types I and III pantothenate kinases from Bacillus subtilis2012

    • Author(s)
      Yuta Ogata, Yuka Tokutake, Shigeru Chohnan
    • Organizer
      112th General Meeting, American Society for Microbiology
    • Place of Presentation
      Moscone Convention Center at San Francisco(アメリカ)
    • Year and Date
      2012-06-19
  • [Presentation] 枯草菌の原核I型およびIII型パントテン酸キナーゼの性質2011

    • Author(s)
      緒形雄太、長南茂
    • Organizer
      第27回日本微生物生態学会大会
    • Place of Presentation
      京都大学
    • Year and Date
      2011-10-09
  • [Presentation] A coenzyme A biosynthetic pathway in archaea2011

    • Author(s)
      Hiroki Katoh, Hideyuki Tamaki, Yuka Tokutake, Satoshi Hanada, Shigeru Chohnan
    • Organizer
      111th General Meeting, American Society for Microbiology
    • Place of Presentation
      Ernest N. Morial Convention Center at New Orleans(アメリカ)
    • Year and Date
      2011-05-24
  • [Presentation] メタン生成古細菌のコエンザイムA生合成経路2010

    • Author(s)
      加藤広己、長南茂
    • Organizer
      日本微生物生態学会第26回大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2010-11-25
  • [Presentation] Pantothenate kinase from thermoacidophilic archaeon2010

    • Author(s)
      Masakazu Takagi, Yukiko Miyamoto, Hedeyuki Tamaki, Roberta Leonardi, Satoshi Hanada, Suzanne Jackowski, Shigeru Chohnan
    • Organizer
      110th General Meeting, American Society for Microbiology
    • Place of Presentation
      San Diego Convention Center(アメリカ)
    • Year and Date
      2010-05-24
  • [Remarks]

    • URL

      http://info.ibaraki.ac.jp/Profiles/5/0000444/profile.html

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Published: 2014-08-29  

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