2012 Fiscal Year Final Research Report
Elucidation of the molecular mechanism underlying the prospore membrane formation in Saccharomyces cerevisiae and its application
| Project/Area Number |
22580076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 微生物学 / 生体膜 |
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| Research Abstract |
Prospore membrane formation of budding yeast is studied as a model system for membrane biogenesis. In this study, we performed domain analysis on protein phosphatase type I targeting subunit, Gip1, and showed that distinct domains are required for its localization and function. We also showed that Spo71 and Spo73, peripheral membrane proteins required for prospore membrane formation, interact together on prospore membrane. Spo73 is a dysferlin domain-only protein. Our analysis on Spo73 provides some clues to elucidate the mechanism of a type of muscular dystrophy caused by mutations in dysferlin domain of dysferlin.
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