2012 Fiscal Year Final Research Report
Characterization ofEcl1familygenesinvolvedinthechronological lifespan in fission yeast.
| Project/Area Number |
22580079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Nagoya University |
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Principal Investigator |
AIBA Hirofumi 名古屋大学, 創薬科学研究科, 教授 (60211687)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 酵母 / 寿命 / 老化 |
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| Research Abstract |
Understanding of lifespan is one of the important theme in current biology. In this study I analyzed the function of Ecl1 family proteins that extend chronological lifespan of fission yeast when overproduced. I also carried out genetical screening to identify novel factors involved in the regulation of chronological lifespan in fission yeast. As a consequence, I have succeeded to reveal mechanisms of Ecl1 functioning and identified novel factors that are involved in the regulation of chronological lifespan in fission yeast. These results should contribute to better understanding of lifespan in higher eukaryote.
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Research Products
(28 results)
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[Journal Article] Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.2012
Author(s)
Ohtsuka, H., Azuma, K., Kubota, S., Murakami, H.,Giga-Hama, Y.,Tohda,H. and Aiba, H.
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Journal Title
Genes to Cells.
Volume: 17
Pages: 39-52
Peer Reviewed
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[Journal Article] Ecl1, a regulator ofthechronologicallifespan of Schizosaccharomyces pombe , is induced upon nitrogen starvation.2011
Author(s)
Miwa, Y., Ohtsuka, H., Naito, C., Murakami, H. and Aiba, H.
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Journal Title
Biosci. Biotech.Biochem.
Volume: 75
Pages: 279-283
Peer Reviewed
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[Journal Article] Pma1, a P-type proton ATPase, i s a determinant of chronological lifespan in fission yeast.2010
Author(s)
Ito, H.,Oshiro,T.,Fujita,Y.,Kubota, S., Ohtsuka,H., H.,Naito,C.,Murakami, and Aiba, H.
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Journal Title
J. Biol. Chem.
Volume: 285
Pages: 34616-34620
Peer Reviewed
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[Presentation] Pma1, a P-type proton ATPase, is a determinant of chronological lifespan in fission yeast2011
Author(s)
Hirokazu Ito, Tomoko Oshiro, Yasuyuki Fujita, Sachiko Kubota, Chikako Naito, Hokuto Ohtsuka, Hiroshi Murakami, and Hirofumi Aiba.
Organizer
The 6 th international fission yeast meeting
Place of Presentation
Boston, USA
Year and Date
20110625-30
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