2012 Fiscal Year Final Research Report
Iron homeostasis regulated by the CCAAT-binding complex in filamentous fungi.
| Project/Area Number |
22580080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Meijo University |
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Principal Investigator |
KATO Masashi 名城大学, 農学部, 教授 (70242849)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 麹菌 / 糸状菌 / 転写因子 / 鉄 / 恒常性 |
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| Research Abstract |
Research on the HapX, a regulator involved in iron homeostasis in filamentous fungi led to some new findings, as follows. 1) Hap B/C/E complex-dependent specific bind- ing property of HapX to the promoters of genes coding iron containing proteins such as cytochrome c. has been elucidated. 2) In vivo analysis revealed the involvement of HapX in the iron homeostasis. 3) Truncated mutants of HapX and the truncated recombinant HapX were obtained to use for the future domain analysis of HapX.
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