2012 Fiscal Year Final Research Report
Studies on the epigenetic regulation of meiosis/sporulation in the budding yeast Saccharomyces serevisiae
| Project/Area Number |
22580086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Hiroshima University |
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Principal Investigator |
TSUCHIYA Eiko 広島大学, 大学院・先端物質科学研究科, 教授 (90127671)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞応答 |
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| Research Abstract |
We explored the function of Rpd3/HDAC on the initiation and progression of meiosis/sporulation inthe budding yeast Saccharomyces cerevisiae, and found the followings. 1) HDAC activity of Rpd3 is repressed by the cooperation of multiple factors including at least Hac1 and Set3 upon induction of early-meiotic gene IME2. 2) Rpd3/HDAC positively regulates the expression of NDT80, encoding a key regulator of mid- and late-meiotic/spoluration genes, through facilitating the release of Sum1/Hst1 transcriptional repressor.
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Research Products
(28 results)
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[Journal Article] Bioorg.Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants2012
Author(s)
K. Kimura, Y. Sakamoto, N. Jujiwawa, S. Uesugik N. Aburai, M. Kawada, S. Ohba, T. Yamori, E. Tsuchiya, and H. Koshino
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Journal Title
Med. Chem
Volume: 20
Pages: 3887-3897
Peer Reviewed
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[Journal Article] Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation2011
Author(s)
Katsunori Takahashi, Ryota Imano, Tatsuya Kibe, Hiroyuki Seimiya, Yukiko Muramatsu, Naoki Kawabata, Genki Tanaka, Yoshitake Matsumoto, Taisuke Hiromoto, Yuka Koizumi, Norihiko Nakazawa, Mitsuhiro Yanagida, Masashi Yukawa, Eiko Tsuchiya, and Masaru Ueno
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Journal Title
Mol. Cell. Biol
Volume: 31
Pages: 495 - 506
Peer Reviewed
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