2012 Fiscal Year Final Research Report
Approach toward the practical use of thermotolerant DNA repair promoting protein by structure-machinery analysis
| Project/Area Number |
22580098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
NARUMI Issay 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究主幹 (90343920)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMADA Mitsugu 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 任期付研究員 (80510924)
FUJIWARA Satoru 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究主幹 (10354888)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 放射線 / 遺伝子 / 微生物 / タンパク質 / DNA 修復 / 耐熱性 |
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| Research Abstract |
The role of DNA repair promoting protein PprA in the moderately thermophilic radioresistant bacterium Deinococcus geothermalis was revealed by a combination of molecular genetics, structural biology and biochemistry. X-ray crystal structure analysis revealed that the basic heptamer structure of the Deinococcus radiodurans DdrA that responds to DNA damage along with PprA protein.
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