2012 Fiscal Year Final Research Report
Biological function and gene regulation of epididymal-specific carboxylesterase (CES4)
| Project/Area Number |
22580100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Iwate University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIMATSU Masami 北海道大学, 遺伝子病制御研究所, 准教授 (70241370)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 精巣上体 / エステラーゼ / 酵素 |
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| Research Abstract |
The biological function of an epididymal-specific carboxylesterase, CES4, was studied using Ces4 knock out mouse. The metabolome analysis of epididymal cell extracts revealed that the most of the glutathione was identified as oxidative form in the epididymis of KO mouse. The expression of oxidative stress-responsive heme oxygenase-1 (HO-1) was also increased in the KO mouse tissue. These data indicated that the epididymis of KO mouse was exposed by oxidative stress.
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Research Products
(4 results)
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[Journal Article] Characterisation of the carboxylesterase enzyme cauxin in the seminal fluid of the cat2011
Author(s)
Miyazaki, M., Miyazaki, T., Toyonaga, M., Tsutsui, T., Taira, H., Yamashita, T. and Suzuki, A.
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Journal Title
The Veterinary Journal
Volume: Vol. 190
Pages: 378-382
Peer Reviewed
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[Journal Article] Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins2010
Author(s)
Holmes, R., Wright, M., Laulederkind, S., Cox, L., Hosokawa, M., Imai, T., Ishibashi, S., Lehner, R., Miyazaki, M., Perkins, E., Potter, P., Redinbo, M., Robert, J., Satoh, T., Yamashita, T., Yan, B., Yokoi, T., Zechner, R. and Maltais, L. J.
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Journal Title
Mammalian Genome
Volume: Vol. 21
Pages: 427-441
Peer Reviewed
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