2012 Fiscal Year Final Research Report
Analysis of hibernation-associated gene regulation in chipmunk
| Project/Area Number |
22580107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KODERA Yoshio 北里大学, 理学部, 准教授 (60265733)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 冬眠 / 転写制御 / 概年リズム / 肝臓 |
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| Research Abstract |
Mammalian hibernation is a seasonal phenomenon with a circannual rhythm, and molecular mechanisms that govern hibernation-associated gene regulation in a circannual manner are still unknown. In the chipmunk, a mammalian hibernator, HSP70 gene transcription in the liver is activated in nonhibernating animals, and repressed in hibernating animals. In this study, we analyzed the hibernation-associated transcriptional regulation of the HSP70 gene, and revealed that the protein levels of HSF-1 and HSF-2 oscillate between the nonhibernating and hibernating seasons, resulting in the hibernation-associated transcriptional regulation of the HSP70 gene.
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[Journal Article] Identification of bovine hibernation-specific protein complex and evidence of its regulation in fasting and aging2013
Author(s)
Fujita, S., Okamoto, R., Taniguchi, M., Ban-Tokuda, T., Konishi, K., Goto, I., Yamamoto, Y., Sugimoto, K., Takamatsu, N., Nakamura, M., Shiraki, K., Buechler, C., Ito, M.
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Journal Title
J. Biochem
Volume: 153巻
Pages: 453-461
DOI
Peer Reviewed
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