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2012 Fiscal Year Final Research Report

Molecular mechanisms of transcriptional regulationProitnobothrops flavoviridis venom gland.

Research Project

  • PDF
Project/Area Number 22580109
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied biochemistry
Research InstitutionSojo University

Principal Investigator

ODA-UEDA Naoko  崇城大学, 薬学部, 教授 (70211828)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Hitomi  崇城大学, 薬学部, 助手 (60510691)
OHKURI Takatoshi  崇城大学, 薬学部, 准教授 (70346807)
Project Period (FY) 2010 – 2012
Keywords遺伝子発現
Research Abstract

Protobothrops flavoviridis snakes inhabit the southwestern islands of Japan. P. flavoviridis venom gland is a treasure-house of the biologically active proteins which act on the target with high specificity. These proteins are regarded as the valuable seeds for drug invention. Here, we have studied to understand the molecular mechanism of transcriptional regulation of gene expression for venomous proteins in P. flavoviridis venom gland.

  • Research Products

    (27 results)

All 2013 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (21 results) Remarks (1 results)

  • [Journal Article] Structual characteristics and evolution of the Protobothrops elegans pancreatic phospholipase A2 gene in contrast with those of Protobothrops genus venom phospholipase A2 genes. Biosci.2013

    • Author(s)
      Chijiwa T., Nakasone H., Irie S., Ikeda N., Tomoda K., Oda-Ueda, N., Hattori S., Ohno M.
    • Journal Title

      Biotechnol. Biochem.

      Volume: 77 Pages: 97-102

    • DOI

      DOI 10.1271/bbb.120595

    • Peer Reviewed
  • [Journal Article] Structural characteristics and evolution of a novelvenom phospholipase A2 gene from Protobothrops flavoviridis.2012

    • Author(s)
      Chijiwa T, Ikeda N, Masuda H, Hara H, Oda-Ueda N, Hattori S, Ohno M.
    • Journal Title

      Biosci. Biotech. Biochem.

      Volume: 76 Pages: 551-558

    • DOI

      DOI 10.1271/bbb.110848

    • Peer Reviewed
  • [Journal Article] Comparative analysis of cells and proteins of pumpkin plants for the control of fruit size2012

    • Author(s)
      Ohshima Y, Nakata Y, Taniguchi G, TakazakiS, Oda-Ueda N, Miyahara K
    • Journal Title

      J. Biosci.

      Volume: 114 Pages: 334-341

    • DOI

      DOI 10.1016/j.jbiosc.2012.04.005

    • Peer Reviewed
  • [Journal Article] A [Lys49]phospholipase A2 from Protobothrops flavoviridis venom induces caspase-independent apoptotic cell death accompanied by rapid plasma membrane rupture in human leukemia cells.2011

    • Author(s)
      Murakami T, Kamikado N, Fujimoto R, Hamaguchi K, Nakamura H, Chijiwa T, Ohno M, Oda-Ueda N.
    • Journal Title

      Biosci. Biotech. Biochem.

      Volume: 75 Pages: 864-870

    • DOI

      DOI 10.1271/bbb.100783

    • Peer Reviewed
  • [Journal Article] Identification and evolution of venom phospholipase A2 inhibitors from Protobothrops elegans serum.2011

    • Author(s)
      So S, Murakami T, Ikeda N, Chijiwa T, Oda-Ueda N, Kuraishi T, Hattori S, Ohno M.
    • Journal Title

      Biosci. Biotech. Biochem.

      Volume: 75 Pages: 480-488

    • DOI

      DOI 10.1271/bbb.100676

    • Peer Reviewed
  • [Presentation] ハブ毒筋壊死因子に対するモノクローナル抗体の作製2013

    • Author(s)
      大栗誉敏、中村仁美、志垣隆通、千々岩崇仁、大野素徳、上田直子
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-29
  • [Presentation] The N-terminal region of[Lys49]phospholipases A2 from Protobothrops flavoviridis venom is an essential element for its cell death andmyonecrotic activities.2012

    • Author(s)
      大栗誉敏、中村仁美、千々岩崇仁、 服部正策、大野素徳、上田直子
    • Organizer
      第85回 日本生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
  • [Presentation] Vascular permeability enhancing activity of Gloydius tsushimaensis venom is due to its vascular endothelial growth factor-like protein2012

    • Author(s)
      中村仁美、村上達夫、今村隆寿、鳥羽通久、 千々岩崇仁、大野素徳、上田直子
    • Organizer
      第85回 日本生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
  • [Presentation] Genetic Divergence of Mitochondria genome sequence among island populations of Japanese Habu snakes Protobothrpos2012

    • Author(s)
      Hiroki Shibata, Mayumi Yamamoto, Takahito Chijiwa, Shosaku Hattori, Naoko Oda-Ueda, Motonori Ohno, Yasuyuki Fukumaki
    • Organizer
      第35回 日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
  • [Presentation] ハブ毒ホスホリパーゼ A2 の構 造・機能と分子進化 in "ホスホリパーゼ A2 織りなす多元的世界2012

    • Author(s)
      上田直子
    • Organizer
      23rd Forum in Doji
    • Place of Presentation
      熊本
    • Year and Date
      2012-11-16
  • [Presentation] A novel vascular endothelial groth factor like protein from Gloydius tsushimaensis venom2012

    • Author(s)
      Hitomi Nakamura, Tasuo Murakami, Takahisa Imamura, Michihisa Toriba, Takahito Chijiwa, Motonori Ohno, Naoko Oda-Ueda
    • Organizer
      17th world Congress of theInternational society on toxinology
    • Place of Presentation
      Honolulu,Hawai, USA
    • Year and Date
      2012-07-12
  • [Presentation] Monotonori Ohno Structural Characteristics and evolution of a novel venom phospholipase A2 gene from Protobothrops flavoviridis2012

    • Author(s)
      Takahito Chijiwa, Naoki Ikeda, Haruna Masuda, Hiroaki Hara, Naoko Oda-Ueda
    • Organizer
      17th world Congress of the International society on toxinology
    • Place of Presentation
      Honolulu, Hawai, USA
    • Year and Date
      2012-07-09
  • [Presentation] BrCN処理によるPLA2アイソザイムの細胞死誘導活性の消失2012

    • Author(s)
      大栗誉?、中村仁美、千々岩崇仁、大野素徳、上田直子
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-27
  • [Presentation] ハブの情報基盤として の遺伝子カタログの作製2012

    • Author(s)
      中村仁美、柴田弘紀、服巻保幸、森一樹、 田代康介、久原哲、千々岩崇仁、大野素徳、 上田直子 奄美大島
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-26
  • [Presentation] 日本固有の毒蛇ハブ(Protobothropsflavoviridis)の島集団間の遺伝的分化2012

    • Author(s)
      柴田弘紀、山本真由美、千々岩崇仁、服部正策、上田直子、大野素徳、服巻保幸
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-26
  • [Presentation] ハブ幼蛇と成蛇の毒成分の比較 解析2012

    • Author(s)
      中村仁美、河野真由、村上達夫、大栗誉?、 森口一、千々岩崇仁、大野素徳、上田直子 奄美大島
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
  • [Presentation] ハブ毒ホスホリパーゼA2アイソザイムの細胞死誘導活性に関わる立体構造領域2012

    • Author(s)
      大栗誉?、中村仁美、千々岩崇仁、大野素徳、上田直子
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-29
  • [Presentation] 毒動物(ハブ)ベノミクスの現状と展望2011

    • Author(s)
      上田直子
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
  • [Presentation] ゲノム構造比較で見いだされたハブ毒ホスホリパーゼA2(祖先型)とPLA2アイソザイム遺伝子が辿った進化過程2011

    • Author(s)
      千々岩崇仁、池田直樹、益田晴奈、原弘昭、上田直子、服部正策、大野素徳
    • Organizer
      第84回日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-21
  • [Presentation] Naoko Oda-Ueda [Lys49]phospholipase A2 from Protobothrops flavoviridis venom induce caspase-independent apoptotic cell death accompanied by rapid plasma membrane rupture in human leukemia cells.2011

    • Author(s)
      Tasuo Murakami, Hitomi Nakamura, Takahito Chijiwa, Takatoshi Ohkuri, Takahito Chjiwa, Motonori Ohno
    • Organizer
      17th World Congress of theEuropean section of the International Societyon Toxinology
    • Place of Presentation
      Valencia (Spain)
    • Year and Date
      2011-09-13
  • [Presentation] ハブ毒ホスホリパーゼA2アイソザイムが誘導する細胞死について2011

    • Author(s)
      上田直子、村上達夫、神門伸幸、藤本量、濱口和廣、中村仁美、千々岩崇仁、大野素徳
    • Organizer
      第58回トキシンシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-07-07
  • [Presentation] ハブ毒腺中のDNAポリメラーゼのcDNAクローニングと発現解析2011

    • Author(s)
      中村仁美、村上達夫、大栗誉?、千々岩崇仁、大野素徳、上田直子
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
  • [Presentation] ツシママムシ毒中の血管透過性亢進因子の同定と諸性質2010

    • Author(s)
      村上達夫、今村隆寿、鳥羽通久、中村仁美、千々岩崇仁、大野素徳、上田直子
    • Organizer
      年12月10日第33回日本分子生物学会、第83回日本生化学会、合同大会、BMB
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
  • [Presentation] ハブ由来のDNAポリメラーゼのクローニングと発現解析2010

    • Author(s)
      中村仁美、村上達夫、大栗誉?、千々岩崇仁、大野素徳、上田直子
    • Organizer
      第33回日本分子生物学会、第83回日本生化学会合同大会、BMB
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] Interisland evolution of venom phospholipase A2 isozymes from Protobothrops flavoviridis in the southwestern islands of Japan.2010

    • Author(s)
      Kantarou Tomoda, Takahito Chijiwa, Tomohisa, Ogawa, Naoko Oda-Ueda, Shosaku Hattori
    • Organizer
      第33回日本分子生物 学会、第83回日本生化学会 合同大会、 BMB
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
  • [Presentation] ハブ毒ホスホリパーゼ A2 アイソザイム遺 伝子クラスター領域の独特の構造と進化2010

    • Author(s)
      千々岩崇仁、池田直樹、松原和純、上田 直子、服部正策、松田洋一、大野素徳
    • Organizer
      第34回酵素の構造と機 能に関する九州シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2010-09-09
  • [Remarks]

    • URL

      http://www.ph.sojo-u.ac.jp/~nakamura/homepage/projects.html

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Published: 2014-08-29   Modified: 2015-11-26  

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