2012 Fiscal Year Final Research Report
Total synthesis and investigation of biologically active natural compounds with novel and complex structures and its application to the development of agricultural and pharmaceutical lead compounds
| Project/Area Number |
22580112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
KIYOTA Hiromasa 東北大学, 大学院・農学研究科, 准教授 (30234397)
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| Co-Investigator(Renkei-kenkyūsha) |
UCHIDA Takafumi 東北大学, 大学院・農学研究科, 教授 (80312239)
USUI Takeo 筑波大学, 大学院・生命環境科学研究科, 准教授 (60281648)
KAWATANI Makoto 独立行政法人理化学研究所, 基幹研究所, 研究員 (50391925)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 抗生物質 / 植物毒素 / 海洋天然物 / ジャスモン酸 / タキサンジテルペノイド / 単離構造決定 / 全合成 / 構造活性相関 |
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| Research Abstract |
Bioorganic research on biologically active natural products have been achieved. 1. Isolation and structure elucidation: the Canadian and Japanese yews, kaya tree, plant Achille, plant Inula, fungus Aspergillus. 2. Synthetic studies: echinopines (plant terpenoids), maoecrystal V (plant terpenoid), cortistatins (marine products) and EI-hybrids A-D, JBIR-23 (antibiotic), platensimycin (antibiotic),enacyloxins (antibiotics).
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[Journal Article] New 686-Taxanes Isolated from the Heartwood of Taxus cuspidata2012
Author(s)
K. Zhang, Y.-L., Z.-Y. Ni, M.-L. Zhang, Y.-F. Wang, M. Dong, Q.-W. Shi, C.-H. Huo, F. Sauriol, H. Kiyota, Y.-C. Gu, B. Cong
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Journal Title
Helv. Chim. Acta
Volume: 95巻
Pages: 1566-1572
DOI
Peer Reviewed
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[Journal Article] Novel Taxa-4(20),12-diene and2(3->20)Abeotaxane from Needles of Taxus canadensis2011
Author(s)
Z.-Y. Ni, Y.-B. Wu, M.-L. Zhang, Y.-F.Wang, M. Dong, F. Sauriol, C.-H. Huo, Q.-W. Shi, Y.-C. Gu, H. Kiyota, and B. Cong
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Journal Title
Biosci. Biotechnol. Biochem
Volume: 75巻
Pages: 1698-1701
DOI
Peer Reviewed
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