2012 Fiscal Year Final Research Report
Synthetic and Structural Studies on Bioactive Natural Products
| Project/Area Number |
22580115
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
ISHIGAMI Ken 東京大学, 大学院・農学生命科学研究科, 准教授 (70292787)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 有機化学 / 天然物化学 / 立体化学 / 抗ピロリ菌 / セスキテルペン / ラジカル環化 |
|---|
| Research Abstract |
Synthetic studies on bioactive natural products, which could be new drugs, were carried out in order to determine their stereochemistry. A new sesquiterpene, potent inhibitor of H. pylori growth, was efficiently synthesized as a racemate via tandem radical cyclization. The stereochemistry of topsentolide A was determined by synthesis of their possible stereoisomers, and cytotoxicity of the synthetic isomers was examined. About Majusculoic acid, a novel antifungal drug, new method to prepare the chiral building block was established.
|
Research Products
(16 results)
