2012 Fiscal Year Final Research Report
Comparative pharmacological studies on insect inhibitory neurotransmitter receptors
| Project/Area Number |
22580120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Shimane University |
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Principal Investigator |
OZOE Yoshihisa 島根大学, 生物資源科学部, 教授 (80112118)
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| Project Period (FY) |
2010 – 2012
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| Keywords | グルタミン酸 / GABA / レセプター / 昆虫 / 神経伝達物質 / 薬理学 |
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| Research Abstract |
Receptors that play an inhibitory synaptic transmission in insect nervous systems are an important target for agrochemicals. In the present study, the significance of inhibitory glutamate receptors (iGluRs) as an agrochemical target was examined by comparing their tissue distribution, function, and pharmacological properties with those of γ-aminobutyric acid receptors (GABARs) from a variety of viewpoints. The results indicated that GABARs have more potential than iGluRs.
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