2012 Fiscal Year Final Research Report
Study on the mechanism of multi-function of food-derived anti-angiogenic compounds and their application
| Project/Area Number |
22580130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血管新生 / 多機能性 / 血管内皮細胞 / 神経細胞 / 脳 / オートファジー |
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| Research Abstract |
It has been demonstrated that antiangiogenic activity is a common biological activity of food-derived bioactive compounds that are useful for human health. In this study, the molecular mechanisms how such compounds exert various useful effects on human health were investigated. Consequently, it has been revealed that the compounds affect gene expression, cell signaling pathways, and autophagy. Oral administration of the compound prevents brain function in animal aging model.
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