2012 Fiscal Year Final Research Report
Mechanism of inhibitory activityof lipolysis by basic polypeptide.
| Project/Area Number |
22580134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Ehime University |
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Principal Investigator |
TSUJITA Takahiro 愛媛大学, 総合科学研究支援センター, 准教授 (60112265)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 栄養学 / 脂質 / 食品 / 肥満 |
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| Research Abstract |
We discovered that the basic biopolymers such as basic polypeptide was strong inhibitors of pancreatic lipase reaction. They might interact with substrate surface and inhibit lipolysis and have anti-obesity function that act by inhibiting intestinal absorption of dietary fat. The lipase inhibition increased with the degree of polymerization of basic amino acids up to 10. The basic polypeptide might be strong lipase inhibitors and free from side effect. Therefore, they could be considered a potential new tool to prevent obesity.
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