2012 Fiscal Year Final Research Report
Analysis of skeletal muscle fiber type transition by fatty acids using isolated fiber culture system
| Project/Area Number |
22580136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
MIZUNOYA Wataru 九州大学, 大学院・農学研究院, 助教 (20404056)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEUCHI Yoshihide 九州大学, 大学院・農学研究院, 教授 (90168112)
TATSUMI Ryuichi 九州大学, 大学院・農学研究院, 准教授 (40250493)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 栄養化学 / 骨格筋 / 筋線維型 / 脂肪酸 |
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| Research Abstract |
Skeletal muscle fibers are classified as slow-type and fast-type based on color, metabolism and contractile properties. Here, we tested whether food component could affect muscle fiber type. Here, we succeeded in establishing a rat muscle fiber-culture assay, in which fibersexpress mature myofibrillar proteins. Then, we revealed that PDK4 and UCP3 mRNAs, known target genes of PPARδand abundant in slow-type fibers, were up-regulated when eicosapentaenoic acid (EPA), abundant in fish oil, was added to fiber cultures for 24 hours.
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[Journal Article] Calcium influx through a possible coupling of cation channels impacts skeletal muscle satellite cell activation in response to mechanical stretch2012
Author(s)
Hara M., Tabata K., Suzuki T., Do M.K., Mizunoya W., Nakamura M., Nishimura S., Tabata S., Ikeuchi Y., Sunagawa K., Anderson J.E., Allen R.E. and Tatsumi R
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Journal Title
Am J Physiol Cell Physiol
Volume: 302
Pages: C1741-1750
Peer Reviewed
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[Presentation] Eicosapentaenoic acid affects skeletal muscle fiber types relating factors via PPARo pathway in isolated fibers of rats., Keystone Symposia, Nuclear Receptors and Friends2013
Author(s)
Mizunoya W., Komiya Y., Anderson J.E., Goto T., Takahashi N., Kawada T., Nakamura M., Tatsumi R.and Ikeuchi Y
Organizer
Roles in Energy Homeostasis and Metabolic Dysfunction
Place of Presentation
Alpbach, Austria
Year and Date
2013-04-06
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