2012 Fiscal Year Final Research Report
Development of a method for the synthesis of flavonoid conjugates andevaluation of their physiological functionalities.
| Project/Area Number |
22580139
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Miyagi University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
鈴木 建夫 , 名誉教授 (80005652)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | フラボノイド抱合体 / 硫酸抱合体 / グルクロン酸抱合体 / 抱合体合成 / ポリフェノール / 抗酸化性 / ACE 阻害 |
|---|
| Research Abstract |
To synthesize flavonoid-O-sulfates and flavonoid-O-glucuronides, flavanone, flavone, flavonol and isoflavone were reacted with a sulfur trioxide pyridine and an acetobromo-glucuronide methylester. The products were analyzed by HPLC and purified by Toyopearl HW40 column chromatography. Chemical structures of the products wereidentified by LCMS and 1H-NMR. The yields of flavonoid-sulfates were good but that of glucuronides were poor. The antioxidant activity and ACE inhibiting activity were decreased by sulfation and glucuronidation of flavonoid aglycones.
|
