2012 Fiscal Year Final Research Report
Antioxidant induced decrement of β-amyloid deposits by phase contrast X-ray technique
| Project/Area Number |
22580145
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Tohoru 北里大学, 医療衛生学部, 教授 (10197311)
KAWAKAMI Fumitaka 北里大学, 医療衛生学部, 助教 (50511896)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アルツハイマー病 / βアミロイド蛋白質 / タウ蛋白質 / クルクミン / タウ蛋白質リン酸化 / 位相 X 線画像 |
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| Research Abstract |
Inhibition of Alzheimer’s disease (AD) by antioxidant curcumin has attracted the attention of scientists. Curcumin effect on Alzheimer’s disease was examined for short-term memory impairment, reduced amyloid deposits and tau hyperphoshorylation using AD model mouse. Our study demonstrates that curcumin is not only inhibited Aβ deposition but also to prevent Tau phosphorylation. Thus, curcumin might be considered to prevent the AD.
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