2012 Fiscal Year Final Research Report
Elucidation of anti-obesity effects of hop procyanidins or its depolymerized compounds
| Project/Area Number |
22580148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ホップ / ポリフェノール / プロシアニジン / 肥満 / 糖尿病 / 脂質代謝 / ラット / 抗酸化 |
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| Research Abstract |
Hop (Humulus lupulus L.) pomace contains procyanidin-rich polyphenols, large oligomeric compounds of catechin. Effect of high dose (1%) of dietary hop pomace polyphenols (HP) in OLETF rats, an animal model of type 2 diabetes, was studied. The rats fed HP tended to have a lower body weight and reduced white adipose tissue weight than the rats fed a control diet. Triglyceride levels in both plasma and liver tended to be lower in the HP fed group than in the control group. Thus, dietary HP may exert anti-obesity effect through the ameliorative function on hepatic fatty acid metabolism and inhibition of fat and glucose absorption from intestine.
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