Research on the asymmetry of phospholipid bilayer and the oxidation stability

2012 Fiscal Year Final Research Report

• Project/Area Number: 22580153
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Gifu University
• Principal Investigator: KUBO Kazuhiro 岐阜大学, 教育学部, 准教授 (40360705)
• Project Period (FY): 2010 – 2012
• Keywords: 栄養生化学

Research Abstract

Although the lipid molecular species of inside-and-outside layer in biomembrane phospholipid bilayer differ extremely, influence of the asymmetric distribution for lipid peroxidation in the phospholipid bilayer is disregarded in most of studies. In the present study, it was observed that cholesterol showed the antioxidation ability more than equivalent compared with vitamin E at physiological concentrations, and not only the asymmetry of phospholipid bilayer but also the molecular shape of coexistence phospholipid affected the antioxidation ability of cholesterol. However, the both results of in vitro system and in vivo system were not in agreement.