2012 Fiscal Year Final Research Report
Elucidation of tissue flexibility through morphogenesis of reticular fiber and establishment of new biomarker for meat evaluation
| Project/Area Number |
22580305
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Zootechnical science/Grassland science
|
|---|
| Research Institution | Tokyo University of Agriculture and Technology |
|---|
Principal Investigator |
ARAI Katsuhiko 東京農工大学, 農学部附属硬蛋白質利用研究施設, 教授 (60175940)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | コラーゲン / 筋 / p53 / ΔNp73 |
|---|
| Research Abstract |
The type XII collagen, which was thought to accelerate fibrogensis, was upregulated during myoblast differentiation. To identify the transcription factor that regulate expression of type XII collage gene, it was found that tumor suppressor protein, p53 bind the regulatory region of the gene and p53-inhibitor, DNp73 stimulated expression of the gene. Thus, p53 family regulated extracellular matrix during myogenesis.
|
