2012 Fiscal Year Final Research Report
Regulatory mechanism of hormone gene expression in the anterior pituitary gland in birds
| Project/Area Number |
22580322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 転写因子 / 下垂体 / PREB / PRL / 発生胚 / Pit-1 |
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| Research Abstract |
The regulatory mechanism of bird PRL in the anterior pituitary gland is unique and completely different to that of mammalian PRL. The aims of this study were cloning of chicken PREB and comparison of levels of mRNA expression in the various tissues during embryogenesis. Chicken PREB cDNA shows 70% similarity to human and rat PREB cDNAs. The levels of PREB mRNA showed tissue dependent manner. Interestingly, the changes of levels of PREB mRNA had not been observed in the anterior pituitary gland during embryogenesis. These results suggest that PREB protein participate regulation of various gene. Furthermore, PREB involves activation of PRL gene rather than increase of mRNA levels during late stage of embryogenesis.
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[Journal Article] Characteristics of Reversion to Early Feathering Phenotype in the Late Feathering Line of Nagoya Breed Chickens2011
Author(s)
Nakamura, A, Ishikawa, A, Nagao, K, Watanabe, H, Uchida, M, Kansaku, N.
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Journal Title
The Journal of Poultry Science.
Volume: 48
Pages: 155-161
Peer Reviewed
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