2012 Fiscal Year Final Research Report
Sympathetic regulation on chemoreception of the carotid body.
| Project/Area Number |
22580330
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Iwate University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIZAKI Keiichiro 岩手大学, 農学部, 准教授 (40337994)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 頚動脈小体 / シグナル伝達 / ノルアドレナリン / 低酸素 / 免疫組織化学 / 解剖学 / 生理学 / 獣医学 |
|---|
| Research Abstract |
Sensing of arterial hypoxia by glomus cells in carotid body is regulating by dopamine. In the present study, it is suggested that noradrenaline and serotonin also regulate chemosensitivity of glomus cells in autocrine manner during short term hypoxia. Furthermore, hypoxic gas enhanced activity of the cervical sympathetic trunk, and activate A1 noradrenergic neurons in the caudal region of ventrolateral medulla.
|
