2012 Fiscal Year Final Research Report
The expression mechanism of protease activated receptors with inflammatory stimulations in intestinal myofibroblasts.
| Project/Area Number |
22580334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SATO Koichi 山口大学, 共同獣医学部, 教授 (90205914)
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| Co-Investigator(Kenkyū-buntansha) |
OHAMA Takashi 山口大学, 共同獣医学部, 教授 (50579018)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 筋線維芽細胞 / IMF / SmcMF / LmcMF / プロテアーゼ活性化受容体 |
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| Research Abstract |
The roles of PAR (protease activated receptor） in the intestinal myofibroblast do not fully understand. So, we designed this project to clarify the role of PAR and the control mechanisms of the expression of PAR in intestinal myofibroblasts. We found that the expression level of PAR in the whole cell by the stimulation with cytokines was not changed, but PAR was moved from membrane to cytosolic area. We also found that prostaglandin E2-induced cAMP is contributed in this mechanism.
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