2012 Fiscal Year Final Research Report
Induction of alternative activation of macrophages and alterationsin intestinal epithelial cell function by Th2 cytokines for type 2 diabetes therapy
| Project/Area Number |
22580337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Miyagi University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Keywords | 糖尿病 / マクロファージ / 寄生虫 / GLUT |
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| Research Abstract |
KK-Ay/TaJｃl mice, an animal models of type 2 diabetes were inoculated with infective third-stage Heligmosomoides polygyrus (Hp) larvae and studied at day8 after infection. Th2 cytokine gene expression was elevated, and AAMacs were accumulated in the small intestine. The gene expression of GLUT-2 and SGLT-1 was down regulated. Helminth infection could reduce blood glucose level and the liver enzyme levels and improve a fatty liver. Inducing intestinal AAMacs by Hp infection could have therapeutic importance for T2D.
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