2012 Fiscal Year Final Research Report
Clarification of molecular mechanisms that are involved in development of epilepsy and anxiety.
| Project/Area Number |
22580338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kyoto Sangyo University (2011-2012)
Osaka Prefecture University (2010) |
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Principal Investigator |
KATO Keiko 京都産業大学, 総合生命科学部, 教授 (90252684)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生体情報 |
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| Research Abstract |
α2,3-sialyltransferase (ST3Gal IV) is involved in developments of epilepsy, anxiety, depression, and sleep disorder. In this study, I aimed at the elucidation of the molecular mechanisms of these neuropsychiatric symptoms by using mice deficient for ST3Gal IV gene. Finally, we found that ST3Gal IV controlled the expression level of brain growth hormone that enhances progression of epileptic seizures and was associated with brain lipid metabolism system and production of steroid hormone.
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[Journal Article] Type A1 but Not Type A2 Botulinum Toxin Decreases the Grip Strength of the Contralateral Foreleg Through Axonal Transport From the Toxin-Treated Foreleg of Rats.2011
Author(s)
Torii Y, Akaike N, Harakawa T, Kato K, Sugimoto N, Goto Y, Nakahira S, Kohda T, Kozaki S, Kaji R, Ginnaga A.
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Journal Title
J Pharmacol Sci.
Volume: 117
Pages: 275-285
DOI
Peer Reviewed
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