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2012 Fiscal Year Final Research Report

Functional analysis of cyclophilins on feline infectious peritonitis virus replication

Research Project

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Project/Area Number 22580343
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

TANAKA Yoshikazu  日本獣医生命科学大学, 獣医学部, 講師 (50291159)

Project Period (FY) 2010 – 2012
Keywordsウイルス複製 / サイクロフィリン
Research Abstract

Feline infectious peritonitis virus (FIPV) causes lethal diseases and no effective vaccine or treatment has been developed. These experiments clarified that Cyclosporin A (CsA) strongly inhibits replication and transcription of FIPV. Also, both cellular cyclophilin A (CypA) and cyclophilin B (CypB), which bind to CsA enhanced the FIPV replication. PPIase activities of Cyp are affected the FIPV replication.

  • Research Products

    (11 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Suppression of coronavirus replication by cyclophilin inhibitors.2013

    • Author(s)
      Tanaka Y, Sato Y, Sasaki T.
    • Journal Title

      Viruses

      Volume: 5 Pages: 1250-1260

    • DOI

      doi:10.3390/v5051250.

    • Peer Reviewed
  • [Journal Article] Feline infectious peritonitis virus witha large deletion in the 5' terminal region of spike gene retains its virulence for cats.2012

    • Author(s)
      Terada Y, Shiozaki Y, Shimoda H, Mahmoud HY, Noguchi K, Nagao Y, Shimojima M, Iwata H, Mizuno T, Okuda M, Morimoto M, Hayashi T, Tanaka Y, Mochizuki M, Maeda K.
    • Journal Title

      Journal of General Virology 2012

      Volume: 93(Pt 9) Pages: 1930-4

    • Peer Reviewed
  • [Journal Article] Population genetic structures of Staphilicoccus aureus isolates from cats and dogs in Japan.2012

    • Author(s)
      Sasaki T, Tsubakishita S, Tanaka Y, Ohtsuka M, Hongo I, Fukata T, Kabeya H, Maruyama S, Hirotaki S, Hiramatsu K.
    • Journal Title

      Journal of Clinical Microbiology.

    • Peer Reviewed
  • [Journal Article] Suppression of feline coronavirus replication in vitro by cyclosporin A.2012

    • Author(s)
      Tanaka Y, Sato Y, Osawa S, Inoue M, Tanaka S, Sasaki T.
    • Journal Title

      Veterinary Research

      Volume: 43(1) Pages: 41

    • Peer Reviewed
  • [Journal Article] Multiplex-PCR method for speciesidentification of coagulase-positive staphylococci.2010

    • Author(s)
      Sasaki T, Tsubakishita S, Tanaka Y, Sakusabe A, Ohtsuka M, Hirotaki S,Kawakami T, Fukata T, Hiramatsu K.
    • Journal Title

      Journal of Clinical Microbiology.

      Volume: 48 (3) Pages: 765-769

    • Peer Reviewed
  • [Presentation] ネコ伝染性腹膜炎ウイルスの複製におけるシクロフィリンの役割2011

    • Author(s)
      佐藤由佳
    • Organizer
      第152回日本獣医学会学術集会講演要旨集,Page244
    • Place of Presentation
      大阪
    • Year and Date
      20110900
  • [Presentation] Inhibition of feline infectious peritonitis viral replication by cyclosporine. American Society for Virology meeting2010

    • Author(s)
      Yoshikazu Tanaka
    • Organizer
      29th, Montana State University
    • Place of Presentation
      Bozeman, MO, USA
    • Year and Date
      2010-07-19
  • [Presentation] オリンパス株式会社共催;ランチョンセミナー,予防動物医学の展開2010

    • Author(s)
      田中良和、
    • Organizer
      第149回日本獣医学会学術集会講演要旨集
    • Place of Presentation
      東京・日本獣医生命科学大学
    • Year and Date
      2010-03-26
  • [Book] 「犬と猫の早期疾病診断学」分担猫のウイルス感染症,予防動物医学研究会編2011

    • Author(s)
      田中良和,他
    • Total Pages
      132-136
    • Publisher
      チクサン出版社
  • [Patent(Industrial Property Rights)] ネコ伝染性腹膜炎ウイルス(FIPV)の予2013

    • Inventor(s)
      田中良和
    • Industrial Property Rights Holder
      学校法人日本医科大学
    • Industrial Property Number
      特許第5263729
    • Filing Date
      2013-05-10
  • [Patent(Industrial Property Rights)] ネコ伝染性腹膜炎ウイルス(FIPV)の予2013

    • Inventor(s)
      田中良和
    • Industrial Property Rights Holder
      学校法人日本医科大学
    • Industrial Property Number
      特許第5263730
    • Filing Date
      2013-05-10

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Published: 2014-08-29  

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