2012 Fiscal Year Final Research Report
Functional analysis of cyclophilins on feline infectious peritonitis virus replication
| Project/Area Number |
22580343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ウイルス複製 / サイクロフィリン |
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| Research Abstract |
Feline infectious peritonitis virus (FIPV) causes lethal diseases and no effective vaccine or treatment has been developed. These experiments clarified that Cyclosporin A (CsA) strongly inhibits replication and transcription of FIPV. Also, both cellular cyclophilin A (CypA) and cyclophilin B (CypB), which bind to CsA enhanced the FIPV replication. PPIase activities of Cyp are affected the FIPV replication.
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[Journal Article] Feline infectious peritonitis virus witha large deletion in the 5' terminal region of spike gene retains its virulence for cats.2012
Author(s)
Terada Y, Shiozaki Y, Shimoda H, Mahmoud HY, Noguchi K, Nagao Y, Shimojima M, Iwata H, Mizuno T, Okuda M, Morimoto M, Hayashi T, Tanaka Y, Mochizuki M, Maeda K.
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Journal Title
Journal of General Virology 2012
Volume: 93(Pt 9)
Pages: 1930-4
Peer Reviewed
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